ea0021oc1.2 | Diabetes and metabolism | SFEBES2009
Begum Ghazala
, Stevens Adam
, Oliver Mark
, Connor Kristin
, Challis John
, Bloomfield Frank
, White Anne
Maternal undernutrition influences the development of obesity and diabetes in the adult offspring. Previous work has shown that moderate maternal undernutrition may alter the stressresponse of the hypothalamicpituitaryadrenal (HPA) axis; however, it is not clear if this is the mechanism for consequent obesity in offspring.The aim of this study was to analyse epigenetic changes in the POMC and GR genes in the pituitary as markers of HPA ...